ZTT low loss and large effective area of single mode optical fiber is designed for long distance transmission system, and manufactured with MCVD technique. On the basis of the precise control of the refractive index, the fiber has low attenuation at C and L wave band; meanwhile, increase the effective area to suppress the nonlinear effect, which allows larger incident power, increases the nonlinear tolerance of the transmission system to meet the requirements of long distance and high capacity transmission and provide more system redundancy.